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KMID : 1137820220430060409
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의공학회지
2022 Volume.43 No. 6 p.409 ~ p.416
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Feasibility Study of a Verification Tool for the Treatment of Cervical Intraepithelial Neoplasia Using Relative Electrical Property Change Before and After Laser Irradiation
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Heo Jun-Beom
Zhang Tingting
Oh Tong-In
Park Dong-Choon
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Abstract
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Since the detection of cervical intraepithelial neoplasia (CIN) is increasing due to regular cervical cancer screening, there is a high demand for simpler tools to diagnose and treat CIN in the clinic. In this study, we proposed an electric property of cervical tissue to verify treatment using a laser. At first, we observed the depth and width of ablated cervical tissues for 29 samples according to four different pulse energy of the fractional CO2 laser to find enough pulse energy to reach the basement layer for initiated CIN. And then, the relative frequency differences in impedance spectrum before and after laser irradiation for ten non-CIN samples were collected using bioimpedance spectroscopy with a multi-electrode probe. As a result, the laser ablated the cervical tissues with a depth of more than 300 μm at 100 mJ pulse energy. Also, we confirmed that the relative changes of electrical property for cervical tissue increased as the pulse energy of laser output increased, and the variation between samples decreased. Since the relative change in electrical properties of cervical tissue can be easily and quickly measured, the proposed tech- nique paves the way for further verification and follow-up study of laser treatment for CIN.
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KEYWORD
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Laser treatment, Impedance spectrum, Cervical intraepithelial neoplasia, Verification tool
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